Intramolecular Hydrogen Bonding: A Potential Strategy for More Bioavailable Inhibitors of Neuronal Nitric Oxide Synthase

Selective neuronal nitric oxide synthase (nNOS) inhibitors have therapeutic applications in the treatment of numerous neurodegenerative diseases. Here we report the synthesis and evaluation of a series of inhibitors designed to have increased cell membrane permeability via intramolecular hydrogen bo...

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Main Authors: Labby, Kristin Jansen, Xue, Fengtian, Kraus, James M., Ji, Haitao, Mataka, Jan, Li, Huiying, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303928/
https://ncbi.nlm.nih.gov/pubmed/22370337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.01.037
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