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Intramolecular Hydrogen Bonding: A Potential Strategy for More Bioavailable Inhibitors of Neuronal Nitric Oxide Synthase

Selective neuronal nitric oxide synthase (nNOS) inhibitors have therapeutic applications in the treatment of numerous neurodegenerative diseases. Here we report the synthesis and evaluation of a series of inhibitors designed to have increased cell membrane permeability via intramolecular hydrogen bo...

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Detaylı Bibliyografya
Asıl Yazarlar: Labby, Kristin Jansen, Xue, Fengtian, Kraus, James M., Ji, Haitao, Mataka, Jan, Li, Huiying, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303928/
https://ncbi.nlm.nih.gov/pubmed/22370337
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.01.037
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