Key role of proline-rich tyrosine kinase 2 in interleukin-8 (CXCL8/IL-8)-mediated human neutrophil chemotaxis

The signalling pathways leading to CXCL8/IL-8-induced human neutrophil migration have not been fully characterized. The present study demonstrates that CXCL8 induces tyrosine phosphorylation as well as enzymatic activity of proline-rich tyrosine kinase 2 (Pyk2), a non-receptor protein tyrosine kinas...

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Main Authors: Di Cioccio, Vito, Strippoli, Raffaele, Bizzarri, Cinzia, Troiani, Giulia, Cervellera, Maria Neve, Gloaguen, Isabelle, Colagrande, Antonella, Cattozzo, Elisa Margherita, Pagliei, Sabrina, Santoni, Angela, Colotta, Francesco, Mainiero, Fabrizio, Bertini, Riccardo
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2004
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1782435/
https://ncbi.nlm.nih.gov/pubmed/15056377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2004.01822.x
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