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Use of ferrous iron by metallo-β-lactamases

Metallo-β-lactamases (MBLs) catalyse the hydrolysis of almost all β-lactam antibacterials including the latest generation carbapenems and are a growing worldwide clinical problem. It is proposed that MBLs employ one or two zinc ion cofactors in vivo. Isolated MBLs are reported to use transition meta...

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Publicat a:J Inorg Biochem
Autors principals: Cahill, Samuel T., Tarhonskaya, Hanna, Rydzik, Anna M., Flashman, Emily, McDonough, Michael A., Schofield, Christopher J., Brem, Jürgen
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108564/
https://ncbi.nlm.nih.gov/pubmed/27498591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2016.07.013
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