Comparison of Verona Integron-Borne Metallo-β-Lactamase (VIM) Variants Reveals Differences in Stability and Inhibition Profiles

Metallo-β-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. The Verona integron-borne metallo-β-lactamase (VIM) enzymes are among the most widely distributed MBLs, with >40 VIM varia...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Makena, Anne, Düzgün, Azer Ö., Brem, Jürgen, McDonough, Michael A., Rydzik, Anna M., Abboud, Martine I., Saral, Ayşegül, Çiçek, Ayşegül Ç., Sandalli, Cemal, Schofield, Christopher J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775916/
https://ncbi.nlm.nih.gov/pubmed/26666919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01768-15
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