5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

[Image: see text] Fluorination is a well-known strategy for improving the bioavailability of drug molecules. However, its impact on efficacy is not easily predicted. On the basis of inhibitor-bound protein crystal structures, we found a beneficial fluorination spot for inhibitors targeting methionyl...

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Bibliografiset tiedot
Julkaisussa:ACS Infect Dis
Päätekijät: Zhang, Zhongsheng, Koh, Cho Yeow, Ranade, Ranae M., Shibata, Sayaka, Gillespie, J. Robert, Hulverson, Matthew A., Huang, Wenlin, Nguyen, Jasmine, Pendem, Nagendar, Gelb, Michael H., Verlinde, Christophe L. M. J., Hol, Wim G. J., Buckner, Frederick S., Fan, Erkang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2016
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5108244/
https://ncbi.nlm.nih.gov/pubmed/27627628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.6b00036
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