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Targeting Biomolecules with Reversible Covalent Chemistry

Interaction of biomolecules typically proceeds in a highly selective and reversible manner, for which covalent bond formation has been largely avoided due to the potential difficulty of dissociation. However, employing reversible covalent warheads in drug design has given rise to covalent enzyme inh...

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Podrobná bibliografie
Vydáno v:Curr Opin Chem Biol
Hlavní autoři: Bandyopadhyay, Anupam, Gao, Jianmin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107367/
https://ncbi.nlm.nih.gov/pubmed/27599186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2016.08.011
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