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Targeting Biomolecules with Reversible Covalent Chemistry
Interaction of biomolecules typically proceeds in a highly selective and reversible manner, for which covalent bond formation has been largely avoided due to the potential difficulty of dissociation. However, employing reversible covalent warheads in drug design has given rise to covalent enzyme inh...
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| Pubblicato in: | Curr Opin Chem Biol |
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| Autori principali: | , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5107367/ https://ncbi.nlm.nih.gov/pubmed/27599186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2016.08.011 |
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