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Targeting Biomolecules with Reversible Covalent Chemistry
Interaction of biomolecules typically proceeds in a highly selective and reversible manner, for which covalent bond formation has been largely avoided due to the potential difficulty of dissociation. However, employing reversible covalent warheads in drug design has given rise to covalent enzyme inh...
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| Publicado no: | Curr Opin Chem Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5107367/ https://ncbi.nlm.nih.gov/pubmed/27599186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbpa.2016.08.011 |
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