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Iminoboronate Formation Leads to Fast and Reversible Conjugation Chemistry of α-Nucleophiles at Neutral pH
Bioorthogonal reactions that are fast and reversible under physiologic conditions are in high demand for biological applications. Herein, we show that an ortho boronic acid substituent makes aryl ketones to rapidly conjugate with α-nucleophiles at neutral pH. Specifically, 2-acetylphenylboronic acid...
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| Published in: | Chemistry |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4699557/ https://ncbi.nlm.nih.gov/pubmed/26311464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201502077 |
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