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GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells
Amino acid deprivation is sensed by the eIF2α kinase GCN2. Under conditions of essential amino acid limitation, GCN2 phosphorylates eIF2α, inhibiting the formation of new ternary complex and hence mRNA translation initiation. While decreasing global mRNA translation, eIF2α phosphorylation also incre...
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| Publicado no: | Amino Acids |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5107328/ https://ncbi.nlm.nih.gov/pubmed/27613409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-016-2318-9 |
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