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GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells

Amino acid deprivation is sensed by the eIF2α kinase GCN2. Under conditions of essential amino acid limitation, GCN2 phosphorylates eIF2α, inhibiting the formation of new ternary complex and hence mRNA translation initiation. While decreasing global mRNA translation, eIF2α phosphorylation also incre...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Amino Acids
Egile Nagusiak: Mazor, Kevin M., Stipanuk, Martha H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107328/
https://ncbi.nlm.nih.gov/pubmed/27613409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00726-016-2318-9
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