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Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker
The 2-oxoglutarate-dependent iron enzyme ALKBH3 is an antitumor target and a potential diagnostic marker for several tumor types, including prostate cancer. However, there is at present no simple way to measure this enzyme’s activity. Here we describe a fluorogenic probe design (MAQ) that is directl...
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| Publicado no: | J Am Chem Soc |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5105888/ https://ncbi.nlm.nih.gov/pubmed/26967262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b00986 |
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