Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes

Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemotherapeutic...

Full description

Saved in:
Bibliographic Details
Published in:PLoS Biol
Main Authors: Tran, Thai Q., Ishak Gabra, Mari B., Lowman, Xazmin H., Yang, Ying, Reid, Michael A., Pan, Min, O’Connor, Timothy R., Kong, Mei
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673162/
https://ncbi.nlm.nih.gov/pubmed/29107960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2002810
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items