Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes

Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemotherapeutic...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Tran, Thai Q., Ishak Gabra, Mari B., Lowman, Xazmin H., Yang, Ying, Reid, Michael A., Pan, Min, O’Connor, Timothy R., Kong, Mei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5673162/
https://ncbi.nlm.nih.gov/pubmed/29107960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2002810
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