IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3

Glutamine is an essential nutrient for cancer cell survival and proliferation. Enhanced utilization of glutamine often depletes its local supply, yet how cancer cells adapt to low glutamine conditions is largely unknown. Here, we report that IκB kinase β (IKKβ) is activated upon glutamine deprivatio...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Genes Dev
Hlavní autoři: Reid, Michael A., Lowman, Xazmin H., Pan, Min, Tran, Thai Q., Warmoes, Marc O., Ishak Gabra, Mari B., Yang, Ying, Locasale, Jason W., Kong, Mei
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024682/
https://ncbi.nlm.nih.gov/pubmed/27585591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.287235.116
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky