IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3

Glutamine is an essential nutrient for cancer cell survival and proliferation. Enhanced utilization of glutamine often depletes its local supply, yet how cancer cells adapt to low glutamine conditions is largely unknown. Here, we report that IκB kinase β (IKKβ) is activated upon glutamine deprivatio...

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Detaylı Bibliyografya
Yayımlandı:Genes Dev
Asıl Yazarlar: Reid, Michael A., Lowman, Xazmin H., Pan, Min, Tran, Thai Q., Warmoes, Marc O., Ishak Gabra, Mari B., Yang, Ying, Locasale, Jason W., Kong, Mei
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2016
Konular:
Research Paper
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024682/
https://ncbi.nlm.nih.gov/pubmed/27585591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.287235.116
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