IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3

Glutamine is an essential nutrient for cancer cell survival and proliferation. Enhanced utilization of glutamine often depletes its local supply, yet how cancer cells adapt to low glutamine conditions is largely unknown. Here, we report that IκB kinase β (IKKβ) is activated upon glutamine deprivatio...

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Publicado en:Genes Dev
Main Authors: Reid, Michael A., Lowman, Xazmin H., Pan, Min, Tran, Thai Q., Warmoes, Marc O., Ishak Gabra, Mari B., Yang, Ying, Locasale, Jason W., Kong, Mei
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2016
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Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5024682/
https://ncbi.nlm.nih.gov/pubmed/27585591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.287235.116
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