Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

BACKGROUND: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent reports suggest that L1 is mobile in epithelial tumours...

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Détails bibliographiques
Publié dans:Mob DNA
Auteurs principaux: Carreira, Patricia E., Ewing, Adam D., Li, Guibo, Schauer, Stephanie N., Upton, Kyle R., Fagg, Allister C., Morell, Santiago, Kindlova, Michaela, Gerdes, Patricia, Richardson, Sandra R., Li, Bo, Gerhardt, Daniel J., Wang, Jun, Brennan, Paul M., Faulkner, Geoffrey J.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105311/
https://ncbi.nlm.nih.gov/pubmed/27843499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13100-016-0076-6
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