Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

BACKGROUND: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent reports suggest that L1 is mobile in epithelial tumours...

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Publicado en:Mob DNA
Autores principales: Carreira, Patricia E., Ewing, Adam D., Li, Guibo, Schauer, Stephanie N., Upton, Kyle R., Fagg, Allister C., Morell, Santiago, Kindlova, Michaela, Gerdes, Patricia, Richardson, Sandra R., Li, Bo, Gerhardt, Daniel J., Wang, Jun, Brennan, Paul M., Faulkner, Geoffrey J.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105311/
https://ncbi.nlm.nih.gov/pubmed/27843499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13100-016-0076-6
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