Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

BACKGROUND: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent reports suggest that L1 is mobile in epithelial tumours...

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Detalhes bibliográficos
Publicado no:Mob DNA
Main Authors: Carreira, Patricia E., Ewing, Adam D., Li, Guibo, Schauer, Stephanie N., Upton, Kyle R., Fagg, Allister C., Morell, Santiago, Kindlova, Michaela, Gerdes, Patricia, Richardson, Sandra R., Li, Bo, Gerhardt, Daniel J., Wang, Jun, Brennan, Paul M., Faulkner, Geoffrey J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105311/
https://ncbi.nlm.nih.gov/pubmed/27843499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13100-016-0076-6
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