Evidence for L1-associated DNA rearrangements and negligible L1 retrotransposition in glioblastoma multiforme

BACKGROUND: LINE-1 (L1) retrotransposons are a notable endogenous source of mutagenesis in mammals. Notably, cancer cells can support unusual L1 retrotransposition and L1-associated sequence rearrangement mechanisms following DNA damage. Recent reports suggest that L1 is mobile in epithelial tumours...

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Bibliographic Details
Published in:Mob DNA
Main Authors: Carreira, Patricia E., Ewing, Adam D., Li, Guibo, Schauer, Stephanie N., Upton, Kyle R., Fagg, Allister C., Morell, Santiago, Kindlova, Michaela, Gerdes, Patricia, Richardson, Sandra R., Li, Bo, Gerhardt, Daniel J., Wang, Jun, Brennan, Paul M., Faulkner, Geoffrey J.
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105311/
https://ncbi.nlm.nih.gov/pubmed/27843499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13100-016-0076-6
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