Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

Notch receptors have been implicated as oncogenic drivers in several cancers, the most notable example being NOTCH1 in T-cell acute lymphoblastic leukemia (T-ALL). To characterize the role of activated NOTCH3 in cancer, we generated an antibody that detects the neo-epitope created upon gamma-secreta...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncogene
Prif Awduron: Bernasconi-Elias, Paula, Hu, Tiancen, Jenkins, David, Firestone, Brant, Gans, Sara, Kurth, Esther, Capodieci, Paola, Deplazes-Lauber, Joelle, Petropoulos, Konstantin, Thiel, Phillip, Ponsel, Dirk, Choi, Sung Hee, LeMotte, Peter, London, Anne, Goetcshkes, Margaret, Nolin, Erin, Jones, Michael D., Slocum, Kelly, Kluk, Michael J., Weinstock, David M., Christodoulou, Alexandra, Weinberg, Olga, Jaehrling, Jan, Ettenberg, Seth A., Buckler, Alan, Blacklow, Stephen C., Aster, Jon C., Fryer, Christy J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5102827/
https://ncbi.nlm.nih.gov/pubmed/27157619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2016.133
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