Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression

To test the impact of genetic heterogeneity on cis- and trans-mediated mechanisms of gene expression regulation, we profiled the transcriptome of adipose tissue in 20 inbred congenic strains derived from diabetic Goto–Kakizaki (GK) rats and Brown–Norway (BN) controls, which contain well-defined bloc...

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Detalhes bibliográficos
Publicado no:G3 (Bethesda)
Main Authors: Kaisaki, Pamela J., Otto, Georg W., Argoud, Karène, Collins, Stephan C., Wallis, Robert H., Wilder, Steven P., Yau, Anthony C. Y., Hue, Christophe, Calderari, Sophie, Bihoreau, Marie-Thérèse, Cazier, Jean-Baptiste, Mott, Richard, Gauguier, Dominique
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2016
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100866/
https://ncbi.nlm.nih.gov/pubmed/27646706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.116.033274
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