An easy and efficient inducible CRISPR/Cas9 platform with improved specificity for multiple gene targeting

The CRISPR/Cas9 system is a powerful genome editing tool and has been widely used for biomedical research. However, many challenges, such as off-target effects and lack of easy solutions for multiplex targeting, are still limiting its applications. To overcome these challenges, we first developed a...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Cao, Jian, Wu, Lizhen, Zhang, Shang-Min, Lu, Min, Cheung, William K.C., Cai, Wesley, Gale, Molly, Xu, Qi, Yan, Qin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Methods Online
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100567/
https://ncbi.nlm.nih.gov/pubmed/27458201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw660
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