Elimination of unaltered DNA in mixed clinical samples via nuclease-assisted minor-allele enrichment

Presence of excess unaltered, wild-type (WT) DNA providing no information of biological or clinical value often masks rare alterations containing diagnostic or therapeutic clues in cancer, prenatal diagnosis, infectious diseases or organ transplantation. With the surge of high-throughput technologie...

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Foilsithe in:Nucleic Acids Res
Main Authors: Song, Chen, Liu, Yibin, Fontana, Rachel, Makrigiorgos, Alexander, Mamon, Harvey, Kulke, Matthew H., Makrigiorgos, G. Mike
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2016
Ábhair:
Methods Online
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100565/
https://ncbi.nlm.nih.gov/pubmed/27431322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw650
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