Elimination of unaltered DNA in mixed clinical samples via nuclease-assisted minor-allele enrichment

Presence of excess unaltered, wild-type (WT) DNA providing no information of biological or clinical value often masks rare alterations containing diagnostic or therapeutic clues in cancer, prenatal diagnosis, infectious diseases or organ transplantation. With the surge of high-throughput technologie...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Song, Chen, Liu, Yibin, Fontana, Rachel, Makrigiorgos, Alexander, Mamon, Harvey, Kulke, Matthew H., Makrigiorgos, G. Mike
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Methods Online
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5100565/
https://ncbi.nlm.nih.gov/pubmed/27431322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw650
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