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A Simple Primary Amine Catalyst for Enantioselective α-Hydroxylations and α-Fluorinations of Branched Aldehydes

A new primary amine catalyst for the asymmetric α-hydroxylation and α-fluorination of α-branched aldehydes is described. The products of the title transformations are generated in excellent yields and with high enantioselectivities. Both processes can be performed within short reaction times and on...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Org Lett
Hauptverfasser: Witten, Michael R., Jacobsen, Eric N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098907/
https://ncbi.nlm.nih.gov/pubmed/25952578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.5b01193
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