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Enantioselective fluorination of α-branched aldehydes and subsequent conversion to α-hydroxyacetals via stereospecific C–F bond cleavage

The highly enantioselective fluorination of α-branched aldehydes was achieved using newly developed chiral primary amine catalyst 1. Furthermore, the C–F bond cleavage of the resulting α-fluoroaldehydes proceeded smoothly under alcoholic alkaline conditions to yield the corresponding α-hydroxyacetal...

詳細記述

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書誌詳細
出版年:Chem Sci
主要な著者: Shibatomi, Kazutaka, Kitahara, Kazumasa, Okimi, Takuya, Abe, Yoshiyuki, Iwasa, Seiji
フォーマット: Artigo
言語:Inglês
出版事項: Royal Society of Chemistry 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5975931/
https://ncbi.nlm.nih.gov/pubmed/29910896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03486h
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