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A Simple Primary Amine Catalyst for Enantioselective α-Hydroxylations and α-Fluorinations of Branched Aldehydes

A new primary amine catalyst for the asymmetric α-hydroxylation and α-fluorination of α-branched aldehydes is described. The products of the title transformations are generated in excellent yields and with high enantioselectivities. Both processes can be performed within short reaction times and on...

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Detalhes bibliográficos
Publicado no:Org Lett
Main Authors: Witten, Michael R., Jacobsen, Eric N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098907/
https://ncbi.nlm.nih.gov/pubmed/25952578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.5b01193
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