Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy

Phospholamban (PLN) plays a central role in Ca(2+) homeostasis in cardiac myocytes through regulation of the sarco(endo)plasmic reticulum Ca(2+)-ATPase 2A (SERCA2A) Ca(2+) pump. An inherited mutation converting arginine residue 9 in PLN to cysteine (R9C) results in dilated cardiomyopathy (DCM) in hu...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kuzmanov, Uros, Guo, Hongbo, Buchsbaum, Diana, Cosme, Jake, Abbasi, Cynthia, Isserlin, Ruth, Sharma, Parveen, Gramolini, Anthony O., Emili, Andrew
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098613/
https://ncbi.nlm.nih.gov/pubmed/27742792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606444113
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi