Global phosphoproteomic profiling reveals perturbed signaling in a mouse model of dilated cardiomyopathy

Phospholamban (PLN) plays a central role in Ca(2+) homeostasis in cardiac myocytes through regulation of the sarco(endo)plasmic reticulum Ca(2+)-ATPase 2A (SERCA2A) Ca(2+) pump. An inherited mutation converting arginine residue 9 in PLN to cysteine (R9C) results in dilated cardiomyopathy (DCM) in hu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kuzmanov, Uros, Guo, Hongbo, Buchsbaum, Diana, Cosme, Jake, Abbasi, Cynthia, Isserlin, Ruth, Sharma, Parveen, Gramolini, Anthony O., Emili, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098613/
https://ncbi.nlm.nih.gov/pubmed/27742792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606444113
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