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Oxidation in the complementarity-determining regions differentially influences the properties of therapeutic antibodies
Therapeutic antibodies can undergo a variety of chemical modification reactions in vitro. Depending on the site of modification, either antigen binding or Fc-mediated functions can be affected. Oxidation of tryptophan residues is one of the post-translational modifications leading to altered antibod...
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| Publié dans: | MAbs |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5098445/ https://ncbi.nlm.nih.gov/pubmed/27612038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1231277 |
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