Antibody complementarity determining region design using high-capacity machine learning

MOTIVATION: The precise targeting of antibodies and other protein therapeutics is required for their proper function and the elimination of deleterious off-target effects. Often the molecular structure of a therapeutic target is unknown and randomized methods are used to design antibodies without a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioinformatics
Prif Awduron: Liu, Ge, Zeng, Haoyang, Mueller, Jonas, Carter, Brandon, Wang, Ziheng, Schilz, Jonas, Horny, Geraldine, Birnbaum, Michael E, Ewert, Stefan, Gifford, David K
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Original Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7141872/
https://ncbi.nlm.nih.gov/pubmed/31778140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btz895
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