Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface

Protein-protein interactions are critical determinants in biological systems. Engineered proteins binding to specific areas on protein surfaces could lead to therapeutics or diagnostics for treating diseases in humans. But designing epitope-specific protein-protein interactions with computational at...

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Main Authors: Yu, Chung-Ming, Peng, Hung-Pin, Chen, Ing-Chien, Lee, Yu-Ching, Chen, Jun-Bo, Tsai, Keng-Chang, Chen, Ching-Tai, Chang, Jeng-Yih, Yang, Ei-Wen, Hsu, Po-Chiang, Jian, Jhih-Wei, Hsu, Hung-Ju, Chang, Hung-Ju, Hsu, Wen-Lian, Huang, Kai-Fa, Ma, Alex Che, Yang, An-Suei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310866/
https://ncbi.nlm.nih.gov/pubmed/22457753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033340
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