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An efficient route to bispecific antibody production using single-reactor mammalian co-culture

Bispecific antibodies have shown promise in the clinic as medicines with novel mechanisms of action. Lack of efficient production of bispecific IgGs, however, has limited their rapid advancement. Here, we describe a single-reactor process using mammalian cell co-culture production to efficiently pro...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Shatz, Whitney, Ng, Domingos, Dutina, George, Wong, Athena W., Dunshee, Diana Ronai, Sonoda, Junichiro, Shen, Amy, Scheer, Justin M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098433/
https://ncbi.nlm.nih.gov/pubmed/27680183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1234569
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