Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

Bispecific IgG production in single host cells has been a much sought-after goal to support the clinical development of these complex molecules. Current routes to single cell production of bispecific IgG include engineering heavy chains for heterodimerization and redesign of Fab arms for selective p...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Dillon, Michael, Yin, Yiyuan, Zhou, Jianhui, McCarty, Luke, Ellerman, Diego, Slaga, Dionysos, Junttila, Teemu T., Han, Guanghui, Sandoval, Wendy, Ovacik, Meric A., Lin, Kedan, Hu, Zhilan, Shen, Amy, Corn, Jacob E., Spiess, Christoph, Carter, Paul J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5297516/
https://ncbi.nlm.nih.gov/pubmed/27929752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1267089
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