Precise quantification of mixtures of bispecific IgG produced in single host cells by liquid chromatography-Orbitrap high-resolution mass spectrometry

Bispecific IgG are heterotetramers comprising 2 pairs of heavy and light chains. Co-expression of the 4 component chains in a single host cell typically yields the desired bispecific IgG plus up to 9 additional incorrect chain pairings. Several protein engineering strategies have been reported to fa...

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Publicat a:MAbs
Autors principals: Yin, Yiyuan, Han, Guanghui, Zhou, Jianhui, Dillon, Michael, McCarty, Luke, Gavino, Lou, Ellerman, Diego, Spiess, Christoph, Sandoval, Wendy, Carter, Paul J.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5098441/
https://ncbi.nlm.nih.gov/pubmed/27610742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1232217
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