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Cytosolic Ku70 regulates Bax-mediated cell death
The first known function of Ku70 is as a DNA repair factor in the nucleus. Using neuronal neuroblastoma cells as a model, we have established that cytosolic Ku70 binds to the pro-apoptotic protein Bax in the cytosol and blocks Bax’s cell death activity. Ku70-Bax binding is regulated by Ku70 acetylat...
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| Izdano u: | Tumour Biol |
|---|---|
| Glavni autori: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer Netherlands
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5097087/ https://ncbi.nlm.nih.gov/pubmed/27488115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13277-016-5202-z |
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