KINETICS AND THERMODYNAMICS OF ZINC(II) AND ARSENIC(III) BINDING TO XPA AND PARP-1 ZINC FINGER PEPTIDES

Inhibition of DNA repair is an established mechanism of arsenic co-carcinogenesis, and may be perpetuated by the binding of As(III) to key zinc finger (zf) DNA repair proteins. Validated molecular targets of As(III) include the first zinc finger domain of Poly (ADP-Ribose) Polymerase 1 (PARP-1), and...

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Detalles Bibliográficos
Publicado en:J Inorg Biochem
Main Authors: Huestis, Juliana, Zhou, Xixi, Chen, Li, Feng, Changjian, Hudson, Laurie G., Liu, Ke Jian
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096954/
https://ncbi.nlm.nih.gov/pubmed/27521476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2016.08.003
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