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Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue
Arsenite directly binds to the zinc finger domains of the DNA repair protein poly (ADP ribose) polymerase (PARP)-1, and inhibits PARP-1 activity in the base excision repair (BER) pathway. PARP inhibition by arsenite enhances ultraviolet radiation (UVR)- induced DNA damage in keratinocytes, and the i...
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| Publicado no: | Toxicol Appl Pharmacol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5568456/ https://ncbi.nlm.nih.gov/pubmed/28552776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2017.05.031 |
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