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CRISPR-Cas systems optimize their immune response by specifying the site of spacer integration

CRISPR-Cas systems defend prokaryotes against viruses and plasmids. Short DNA segments of the invader, known as spacers, are stored in the CRISPR array as immunological memories. New spacers are added invariably to the 5′ end of the array, therefore the first spacer matches the latest foreign threat...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: McGinn, Jon, Marraffini, Luciano A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096952/
https://ncbi.nlm.nih.gov/pubmed/27618488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.08.038
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