Supratherapeutic dose evaluation and effect of lesinurad on cardiac repolarization: a thorough QT/QTc study

INTRODUCTION: Lesinurad is a selective uric acid reabsorption inhibitor approved in the United States and Europe for treatment of gout in combination with a xanthine oxidase inhibitor. A maximum tolerated dose study was conducted to determine the lesinurad supratherapeutic dose, followed by a thorou...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Shen, Zancong, Gillen, Michael, Tieu, Kathy, Nguyen, Mai, Harmon, Erin, Wilson, David M, Kerr, Bradley, Lee, Caroline A
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2016
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5096775/
https://ncbi.nlm.nih.gov/pubmed/27826183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S114455
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