Thorough QT/QTc Evaluation of the Cardiac Safety of Secnidazole at Therapeutic and Supratherapeutic Doses in Healthy Individuals

SYM‐1219, a novel oral granule formulation of secnidazole, is under development as single‐dose treatment for bacterial vaginosis. This 4‐way, randomized, crossover study evaluated the effects of SYM‐1219 on electrocardiographic (ECG) parameters in 52 healthy subjects. Subjects were administered sing...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Main Authors: Darpo, Borje, Xue, Hongqi, Adetoro, Nikki, Matthews, Barbara G., Pentikis, Helen S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Drug Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5836856/
https://ncbi.nlm.nih.gov/pubmed/28967984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1014
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