No QTc Prolongation With Zanubrutinib: Results of Concentration‐QTc Analysis From a Thorough QT Study in Healthy Subjects

This thorough QT (TQT) study evaluated the effect of zanubrutinib on electrocardiogram (ECG) parameters by using concentration‐QTc (C‐QTc) analysis as the primary analysis for this study. Part A of the study determined the safety and tolerability of a single supratherapeutic dose of zanubrutinib (48...

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Dettagli Bibliografici
Pubblicato in:Clin Transl Sci
Autori principali: Mu, Song, Darpo, Borje, Tang, Zhiyu, Novotny, William, Tawashi, Manal, Xue, Hongqi, Willett, Michael, Lin, Leo, Sahasranaman, Sri, Ou, Ying C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7485941/
https://ncbi.nlm.nih.gov/pubmed/32144955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cts.12779
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