Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects

AIM: To characterize the effects of lamotrigine on QT interval in healthy subjects. METHODS: Healthy subjects received a single oral dose of moxifloxacin (400 mg) or placebo in crossover design, followed by a dose-escalating regimen of lamotrigine (n = 76) over a 77-day period, or matched placebo (n...

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Hlavní autoři: Dixon, Ruth, Job, Sarah, Oliver, Ruth, Tompson, Debra, Wright, John G, Maltby, Kay, Lorch, Ulrike, Taubel, Jorg
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2008
Témata:
Drug Safety
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2526242/
https://ncbi.nlm.nih.gov/pubmed/18662287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2008.03250.x
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