A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

HIV-1 integrase (IN) is essential for virus replication and represents an important multifunctional therapeutic target. Recently discovered quinoline-based allosteric IN inhibitors (ALLINIs) potently impair HIV-1 replication and are currently in clinical trials. ALLINIs exhibit a multimodal mechanis...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Patel, Disha, Antwi, Janet, Koneru, Pratibha C., Serrao, Erik, Forli, Stefano, Kessl, Jacques J., Feng, Lei, Deng, Nanjie, Levy, Ronald M., Fuchs, James R., Olson, Arthur J., Engelman, Alan N., Bauman, Joseph D., Kvaratskhelia, Mamuka, Arnold, Eddy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2016
Matèries:
Protein Structure and Folding
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095411/
https://ncbi.nlm.nih.gov/pubmed/27645997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753384
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