A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain

HIV-1 integrase (IN) is essential for virus replication and represents an important multifunctional therapeutic target. Recently discovered quinoline-based allosteric IN inhibitors (ALLINIs) potently impair HIV-1 replication and are currently in clinical trials. ALLINIs exhibit a multimodal mechanis...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Patel, Disha, Antwi, Janet, Koneru, Pratibha C., Serrao, Erik, Forli, Stefano, Kessl, Jacques J., Feng, Lei, Deng, Nanjie, Levy, Ronald M., Fuchs, James R., Olson, Arthur J., Engelman, Alan N., Bauman, Joseph D., Kvaratskhelia, Mamuka, Arnold, Eddy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5095411/
https://ncbi.nlm.nih.gov/pubmed/27645997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753384
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados