Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers

Human tumors show a high level of genetic heterogeneity, but the processes that influence the timing and route of metastatic dissemination of the subclones are unknown. Here we have used whole-exome sequencing of 103 matched benign, malignant and metastatic skin tumors from genetically heterogeneous...

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Bibliographic Details
Published in:Nat Med
Main Authors: McCreery, Melissa Q, Halliwill, Kyle D, Chin, Douglas, Delrosario, Reyno, Hirst, Gillian, Vuong, Peter, Jen, Kuang-Yu, Hewinson, James, Adams, David J, Balmain, Allan
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094808/
https://ncbi.nlm.nih.gov/pubmed/26523969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3979
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