Lgr6 is a stem cell marker in mouse skin squamous carcinomas

The G-protein-coupled receptors Lgr4/5/6 are Wnt signalling mediators, but their functions in squamous carcinomas (SCCs) are unclear. Using lineage tracing in Lgr5-EGFP-CreERT2- and Lgr6-EGFP-CreERT2- Rosa26/Tomato reporter mice, we demonstrate that Lgr6, but not Lgr5, acts as an epithelial stem cel...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Huang, Phillips Y., Kandyba, Eve, Jabouille, Arnaud, Sjolund, Jonas, Kumar, Atul, Halliwill, Kyle, McCreery, Melissa, DelRosario, Reyno, Kang, Hio Chung, Wong, Christine E., Seibler, Jost, Beuger, Vincent, Pellegrino, Maurizio, Sciambi, Adam, Eastburn, Dennis J., Balmain, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5662105/
https://ncbi.nlm.nih.gov/pubmed/28945253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3957
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