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FBXW7 Targets mTOR for Degradation and Genetically Cooperates with PTEN in Tumor Suppression

The enzyme mTOR (mammalian target of rapamycin) is a major target for therapeutic intervention to treat many human diseases, including cancer, but very little is known about the processes that control levels of mTOR protein. Here we show that mTOR is targeted for ubiquitination and consequent degrad...

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Detalhes bibliográficos
Main Authors: Mao, Jian-Hua, Kim, Il-Jin, Wu, Di, Climent, Joan, Kang, Hio Chung, DelRosario, Reyno, Balmain, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849753/
https://ncbi.nlm.nih.gov/pubmed/18787170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1162981
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