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FBXW7 Targets mTOR for Degradation and Genetically Cooperates with PTEN in Tumor Suppression
The enzyme mTOR (mammalian target of rapamycin) is a major target for therapeutic intervention to treat many human diseases, including cancer, but very little is known about the processes that control levels of mTOR protein. Here we show that mTOR is targeted for ubiquitination and consequent degrad...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2849753/ https://ncbi.nlm.nih.gov/pubmed/18787170 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1162981 |
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