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Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression

Pten heterozygous (Pten(+/-)) mice develop increased papilloma numbers and show decreased carcinoma latency time in comparison with controls after skin treatment with dimethyl benzanthracene (DMBA) and tetradecanoyl-phorbol acetate (TPA). H-ras mutation is normally a hallmark of DMBA-TPA-induced ski...

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Detalhes bibliográficos
Main Authors: Mao, Jian-Hua, To, Minh D., Perez-Losada, Jesus, Wu, Di, Del Rosario, Reyno, Balmain, Allan
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517400/
https://ncbi.nlm.nih.gov/pubmed/15289454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1213804
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