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Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression
Pten heterozygous (Pten(+/-)) mice develop increased papilloma numbers and show decreased carcinoma latency time in comparison with controls after skin treatment with dimethyl benzanthracene (DMBA) and tetradecanoyl-phorbol acetate (TPA). H-ras mutation is normally a hallmark of DMBA-TPA-induced ski...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC517400/ https://ncbi.nlm.nih.gov/pubmed/15289454 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1213804 |
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