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RNA splicing factors as oncoproteins and tumor suppressors

The recent genomic characterization of cancers has revealed recurrent somatic point mutations and copy number changes affecting genes encoding RNA splicing factors. Initial studies of these ‘spliceosomal mutations’ suggest that the proteins bearing these mutations exhibit altered splice site and/or...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Rev Cancer
Prif Awduron: Dvinge, Heidi, Kim, Eunhee, Abdel-Wahab, Omar, Bradley, Robert K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5094465/
https://ncbi.nlm.nih.gov/pubmed/27282250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc.2016.51
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