β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces

α-Synuclein is an intrinsically disordered protein that is associated with the pathogenesis of Parkinson’s disease through the processes involved in the formation of amyloid fibrils. α and β-synuclein are homologous proteins found at comparable levels in presynaptic terminals but β-synuclein has a g...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Brown, James W. P., Buell, Alexander K., Michaels, Thomas C. T., Meisl, Georg, Carozza, Jacqueline, Flagmeier, Patrick, Vendruscolo, Michele, Knowles, Tuomas P. J., Dobson, Christopher M., Galvagnion, Céline
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093550/
https://ncbi.nlm.nih.gov/pubmed/27808107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36010
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